• TriRegol Tablets (63s)

  • TriRegol Tablets
  • We are currently unable to obtain this medicine due to it being unavailable from the manufacturer. They have not yet provided us with a date as to when it will become available again.
  • TriRegol tablets are a type of hormonal contraception commonly known as 'the pill' or combined oral contraceptive pill. TriRegol tablets contain two active ingredients, ethinylestradiol and levonorgestrel. These are synthetic versions of the naturally occurring female sex hormones, oestrogen and progesterone. Ethinylestradiol is a synthetic version of oestrogen and levonorgestrel is a synthetic form of progesterone.

    Combined oral contraceptives like TriRegol work by over-riding the normal menstrual cycle. In a woman's normal menstrual cycle, levels of the sex hormones change throughout each month. The hormones cause an egg to be released from the ovaries (ovulation) and prepare the lining of the womb for a possible pregnancy. At the end of each cycle, if the egg has not been fertilised the levels of the hormones fall, causing the womb lining to be shed as a monthly period.

    The daily dose of hormones taken in the pill work mainly by tricking your body into thinking that ovulation has already happened. This prevents an egg from ripening and being released from the ovaries each month.

    The hormones also increase the thickness of the natural mucus at the neck of the womb, which makes it more difficult for sperm to cross from the vagina into the womb and reach an egg. They also change the quality of the womb lining (endometrium), making it less likely that a fertilised egg can implant there.

    TriRegol is a triphasic pill. Each 21 day pack contains three types of tablets, each with a slightly different dose of hormones in it. The six pink tablets contain 30 micrograms ethinylestradiol and 50 micrograms levonorgestrel, the five white tablets contain 40 micrograms ethinylestradiol and 75 micrograms levonorgestrel, and the ten ochre tablets contain 30 micrograms ethinylestradiol and 125 micrograms levonorgestrel.

    TriRegol tablets must be taken in the order specified on the pack, starting with the pink tablet marked '1'. One tablet is taken every day for 21 days and you then have a seven day break from pill-taking. During your seven day break, the levels of the hormones in your blood drop, which results in a withdrawal bleed that is similar to your normal period. You start the next pack after the seven pill-free days are up, even if you are still bleeding.

    You will still be protected against pregnancy in your pill-free week, provided you took all the pills correctly, you start the next packet on time and nothing else happened that could make the pill less effective (eg sickness, diarrhoea, or taking certain other medicines).

    You should try and take your pill at the same time every day; this will help you remember to take it. Each tablet should be swallowed with a drink. They can be taken either with or without food.

    Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine.

    • Nausea and vomiting.
    • Abdominal pain.
    • Headache/migraine.
    • Breast tenderness and enlargement.
    • Weight changes.
    • Retention of water in the body tissues (fluid retention).
    • Vaginal thrush (candidiasis).
    • Change in menstrual bleeding, usually lighter periods or sometimes stopping of periods.
    • Menstrual spotting or breakthrough bleeding.
    • Depression.
    • Decreased sex drive.
    • Rise in blood pressure.
    • Skin reactions.
    • Irregular brown patches on the skin, usually of the face (chloasma).
    • Steepening of corneal curvature, which may make contact lenses uncomfortable.
    • Disturbance in liver function.
    • Gallstones.
    • Blood clots in the blood vessels (eg, DVT, pulmonary embolism, heart attack, stroke - see warnings above).

    TriRegol should be used with caution by

    • Women aged over 35 years.
    • Women whose parent, brother or sister had a heart attack or stroke caused by a blood clot before the age of 45.
    • Women with a parent, brother or sister who has had a blood clot in a vein (venous thromboembolism), eg in the leg (deep vein thrombosis) or in the lungs (pulmonary embolism) before the age of 45.
    • Smokers.
    • Women who are obese.
    • Women with diabetes mellitus.
    • Women with high blood pressure (hypertension).
    • Women with heart failure.
    • Women who use a wheelchair.
    • Women with a history of inflammation of a vein caused by a superficial blood clot (thrombophlebitis).
    • Women with anaemia caused by a hereditary blood disorder where abnormal haemoglobin is produced (sickle cell anaemia).
    • Women with a history of severe depression, especially if this was caused by taking the pill in the past.
    • Women with a history of migraines (see above).
    • Women with inflammatory bowel disease, eg Crohn's disease or ulcerative colitis.
    • Women with a personal or family history of raised levels of fats called triglycerides in the blood (hypertriglyceridaemia).
    • Women with raised levels of the hormone prolactin in their blood (hyperprolactinaemia).
    • Women with an undiagnosed breast lump or gene mutations that are associated with breast cancer, eg BRCA1.
    • Women with a history of irregular brown patches appearing on the skin, usually of the face, during pregnancy or previous use of a contraceptive pill (chloasma). Women with a tendency to this condition should minimise their exposure to the sun or UV light while taking this contraceptive.

    The patient information leaflet (PIL) is a leaflet containing specific information about medical conditions, doses and side effects. You can download a copy of the PIL here:

    Patient Info Leaflet TriRegol Tablets Information Leaflet