• Tridestra Tablets (91s)

  • Tridestra
  • Tridestra is a sequential, combined type of type of Hormone Replacement Therapy (HRT) that comes in a form of a tablet. This type of HRT is more suitable for you if you are borderline postmenopausal, having infrequent periods. Femososton’s main components are:

    • estradiol (a naturally occurring form of oestrogen)
    • medroxyprogesterone (a form of progesterone).

    Taking Tridestra will produce a withdrawal bleed once every three months. There are 91 tablets in a pack of Tridestra. You will start by taking white tablets, containing just estradiol, for the first 70 days. From days 71 to 84, you will be taking blue tablets, containing estradiol and medroxyprogesterone. From days 85 to 91, you will be taking yellow tablets with no active ingredient. You will get a withdrawal bleed whilst taking these yellow tablets.

    The estradiol helps to make up for the body’s declining levels of oestrogen, as your ovaries produce less of it in the years approaching the menopause. Off-setting this balance can help reduce some of the more upsetting symptoms of the menopause, such as:

    • irregular periods
    • hot flushes
    • night sweats
    • mood swings
    • vaginal dryness or itching.

    It is worth noting that oestrogen stimulates the lining of the womb and in rare cases, this can lead to endometrial cancer. This is where medroxyprogesterone comes into action; it stops the estradiol’s womb stimulating effect, which reduces the risk of cancer.

    Tridestra tablets come in a 91-day calendar pack. You should take one tablet every day in the order marked on the pack. You should then start the next pack without a break.

    Take one tablet daily. Swallow this tablet whole with a drink either with or without food.

    Your tablet should be taken at around the same time each day; getting into a rhythm should help you to remember to take it.

    If you forget to take a dose at your usual time the missed dose should be taken provided no more than 12 hours have elapsed since you last took a tablet. If your dose is more than 12 hours late, the forgotten dose should be skipped and your next dose should be taken at your usual time. If you take a double dose, this could lead to breakthrough bleeding.

    Please note: if you ever need to have major surgery, please inform us as soon as you know, so that our doctor can advise you on whether to stop taking this medication.

    Your need for HRT should be reviewed by your doctor at least once every twelve months.

    The following side effects can affect individuals in different ways, it does not mean that all will be affected:

    Common: (may affect up to 1 in 10 people)

    • weight increase or decrease, swelling caused by fluid retention
    • depression, nervousness, lethargy
    • nausea, vomiting, stomach cramps, flatulence
    • headache, dizziness
    • hot flushes, sweating
    • breast tension and pain, vaginal discharge, bleeding or spotting, menstrual disorder.

    Uncommon: (may affect up to 1 in 100 people)

    • non-cancerous breast tumour
    • benign growths in the lining of the womb
    • allergic (hypersensitivity) reaction
    • increased appetite, high level of cholesterol in the blood
    • anxiety, inability to sleep, apathy, mood swings, poor concentration, changes in sex drive and mood, euphoria, agitation
    • migraine, sensation of tingling, pricking or numbness in skin, trembling
    • visual impairment, dry eye
    • unusually fast or irregular heartbeat
    • increased blood pressure, superficial inflammation of the veins, redness or red spots on the skin
    • breathlessness, runny or blocked nose
    • constipation, indigestion/heartburn, diarrhoea, rectal disorder
    • acne, hair loss, dry skin, nail problems, skin nodule, excessive hair growth (hirsutism), painful reddish skin nodules (erythema nodosum), generalised itchy rash
    • joint disorders, muscle cramps
    • increased and frequent urge to pass urine, loss of bladder control, bladder infections, discoloured urine, blood in the urine
    • breast enlargement, breast tenderness, thickening of the lining of the womb, uterine disorder
    • tiredness, abnormal laboratory tests, weakness, fever, flu-like symptoms, feeling generally unwell
    • Rare: (may affect up to 1 in 1,000 people)

      • contact lens intolerance
      • alternations in liver function and biliary flow
      • skin rash
      • blood clots in the veins of the legs or lungs
      • menstrual pain, pre-menstrual like syndrome

      The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with Tridestra, please read the information provided with the medicine or consult your doctor or pharmacist.

    Tridestra should be used with caution if you have:

    • fibroids inside your womb
    • a growth of womb lining outside your womb (endometriosis) or a history of excessive growth of the womb lining (endometrial hyperplasia)
    • increased risk of developing blood clots (thrombosis)
    • increased risk of oestrogen-sensitive cancer (the risk is increased if your mother, grandmother or sister has, or has had, breast cancer)
    • high blood pressure
    • a liver disorder, such as a benign liver tumour
    • diabetes
    • gallstones
    • migraine or severe headaches
    • a disease of the immune system that affects many organs of the body (e.g.systemic lupus erythematosus, SLE)
    • epilepsy
    • asthma
    • a disease affecting the eardrum and hearing (otosclerosis)
    • a very high level of fat in your blood (triglycerides)
    • fluid retention due to cardiac or kidney problems
    • hereditary angioedema

    Tridestra should not be used if you:

    • have or have ever had breast cancer, or if you are suspected of having it
    • have cancer which is sensitive to oestrogens, such as cancer of the womb lining (endometrium), or if you are suspected of having it
    • have any unexplained vaginal bleeding
    • have excessive thickening of the womb lining (endometrial hyperplasia) and this is not being treated
    • have or have ever had a blood clot in a vein (thrombosis), such as in the legs (deep venous thrombosis) or the lungs (pulmonary embolism)
    • have a blood clotting disorder (such as protein C, protein S, or antithrombin deficiency)
    • have or recently have had a disease caused by blood clots in the arteries, such as a heart attack, stroke or angina
    • have or have ever had a liver disease and your liver function tests have not returned to normal
    • have a rare blood problem called “porphyria” which is passed down in families (inherited)
    • Tridestra should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you think or feel that you have experienced an allergic reaction, inform your doctor or pharmacist immediately and immediately stop using this medicine.

    The patient information leaflet (PIL) is a leaflet containing specific information about medical conditions, doses and side effects. You can download a copy of the PIL here:

    Patient Info Leaflet Tridestra Tablets Information Leaflet