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  • Livial (Tibolone) 2.5mg Tablets (84s)

  • Livial (Tibolone) 2.5mg Tablets
  • Livial is slightly different to other forms of Hormone Replacement Therapy (HRT), as it contains the synthetic steroid, tibilone. This type of HRT is more suitable for you if you had your last period over twelve months ago. It can also be used if you have had a hysterectomy, or are taking medicines called gonadorelin analogues, e.g. leuprorelin for endometriosis. Tibolone has similar properties to:

    • Oestrogen
    • Progesterone
    • Testosterone

    When taking Livial, you should notice an improvement in your mood and libido.

    Livial can help to prevent osteoporosis (fragile bones) which can develop after menopause. The falling levels of oestrogen after the menopause can promote thinning of the bones and makes them more prone to breaking. It can also help reduce some of the more upsetting symptoms of the menopause, such as:

    • irregular periods
    • hot flushes
    • night sweats
    • mood swings, irritability, anxiousness
    • vaginal dryness or itching.

    Livial does not stimulate the lining of the womb, which means taking Livial will not cause monthly vaginal bleeding (withdrawal bleeding).

    Take one tablet daily. Swallow this tablet whole with a drink either with or without food.

    Your tablet should be taken at around the same time each day; getting into a rhythm should help you to remember to take it.

    If you forget to take a dose at your usual time the missed dose should be taken provided no more than 12 hours have elapsed since you last took a tablet. If your dose is more than 12 hours late, the forgotten dose should be skipped and your next dose should be taken at your usual time. If you take a double dose, this could lead to breakthrough bleeding.

    Please note: if you ever need to have major surgery, please inform us as soon as you know, so that our doctor can advise you on whether to stop taking this medication.

    Your need for HRT should be reviewed by your doctor at least once every twelve months.

    The following side effects can affect individuals in different ways, it does not mean that all will be affected:

    Common (affect between 1 in 10 and 1 in 100 people)

    • Vaginal bleeding or spotting. See warning section above.
    • Vaginal discharge.
    • Vaginal itching.
    • Vaginal thrush.
    • Breast tenderness.
    • Abnormal hair growth (hypertrichosis).
    • Weight gain.
    • Abdominal or pelvic pain.
    • Thickening of the lining of the uterus (endometrium).

    Uncommon (affect between 1 in 100 and 1 in 1000 people)

    • Fluid retention, resulting in swelling (oedema).
    • Acne.
    • Nipple pain.

    Unknown frequency

    • Rash or itching.
    • Seborrhoeic dermatitis.
    • Dizziness.
    • Headache/migraine.
    • Visual disturbances such as blurred vision.
    • Pain in the muscles and joints.
    • Depression.
    • Alteration in results of liver function tests.
    • Irregular brown patches on the skin, usually of the face (chloasma).
    • Gallstones.
    • Blood clots in the blood vessels (e.g. DVT, pulmonary embolism, heart attack).

    The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with Livial, please read the information provided with the medicine or consult your doctor or pharmacist.

    Livial should be used with caution if you have:

    • fibroids inside your womb
    • a growth of womb lining outside your womb (endometriosis) or a history of excessive growth of the womb lining (endometrial hyperplasia)
    • increased risk of developing blood clots (thrombosis)
    • increased risk of oestrogen-sensitive cancer (the risk is increased if your mother, grandmother or sister has, or has had, breast cancer)
    • high blood pressure
    • a liver disorder, such as a benign liver tumour
    • diabetes
    • gallstones
    • migraine or severe headaches
    • a disease of the immune system that affects many organs of the body (e.g.systemic lupus erythematosus, SLE)
    • epilepsy
    • asthma
    • a disease affecting the eardrum and hearing (otosclerosis)
    • a very high level of fat in your blood (triglycerides)
    • fluid retention due to cardiac or kidney problems

    Livial should not be used if you:

    • have or have ever had breast cancer, or if you are suspected of having it
    • have cancer which is sensitive to oestrogens, such as cancer of the womb lining (endometrium), or if you are suspected of having it
    • have any unexplained vaginal bleeding
    • have excessive thickening of the womb lining (endometrial hyperplasia) and this is not being treated
    • have or have ever had a blood clot in a vein (thrombosis), such as in the legs (deep venous thrombosis) or the lungs (pulmonary embolism)
    • have a blood clotting disorder (such as protein C, protein S, or antithrombin deficiency)
    • have or recently have had a disease caused by blood clots in the arteries, such as a heart attack, stroke or angina
    • have or have ever had a liver disease and your liver function tests have not returned to normal
    • have a rare blood problem called “porphyria” which is passed down in families (inherited)
    • Livial should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you think or feel that you have experienced an allergic reaction, inform your doctor or pharmacist immediately and immediately stop using this medicine.

    The patient information leaflet (PIL) is a leaflet containing specific information about medical conditions, doses and side effects. You can download a copy of the PIL here:

    Patient Info Leaflet Livial (Tibolone) 2.5mg Tablets Information Leaflet