Evorel Conti is a continuous combined hormone replacement therapy (HRT), which comes in the form of a patch. This type of HRT is more suitable for you if you had your last period over eighteen months ago. Evorel Conti’s main ingredients are:
- Estradiol (a form of oestrogen)
- Norethisterone (a synthetic form of progesterone)
The estradiol helps to make up for the body’s declining levels of oestrogen, as your ovaries produce less of it in the years approaching the menopause. Offsetting this balance can help reduce some of the more upsetting symptoms of the menopause, such as:
- irregular periods
- hot flushes
- night sweats
- mood swings
- vaginal dryness or itching
The declining level of oestrogen at menopause can also affect the bones, causing them to become thinner and more prone to breaking; a condition known as osteoporosis. Oestrogen can therefore be supplemented to help prevent bone loss and fractures.
It is worth noting that oestrogen stimulates the lining of the womb and, in rare cases, this can lead to endometrial cancer. This is where norethisterone comes into action - it stops the estradiol’s womb stimulating effect, reducing the risk of cancer.
The norothisterone levels in Evorel Conti are lower than those of cyclical combined HRT treatments, as Evorel Conti does not produce a monthly bleed (also called a withdrawal bleed). The patches release the hormones through the skin into the bloodstream at a constant rate and are changed twice per week.
Apply a new patch twice a week (every three to four days) to your buttock or hip, below the waistline. It is best to avoid areas where clothing can cause the patch to rub off.
Do not apply the patch to or near to the breasts.
Each time you apply a new patch, change the site you place it and do not place the patch on that same area for at least a week.
Before you apply the patch to your skin, make sure that your skin is clean and dry, cool, free of any powder, oily moisturise or lotion and free of cuts or irritation.
You can keep the patch on when you have a shower or bath. If the patch falls off, wait until the skin is dry and at a normal temperature before applying a new patch. Replace the patch with a new one immediately. Replace this patch on the scheduled ‘change’ day.
For details on applying the patch, please see the product information leaflet.
If you ever need to have major surgery, please inform us as soon as you know, so that our doctor can advise you on whether to stop taking this medication.
Your need for HRT should be reviewed by your doctor at least once every twelve months.
The following side effects can affect individuals in different ways, it does not mean that all will be affected:
Very common (may affect 1 in 10 people):
- Irritated, itchy, red skin and rash where the patch is applied
Common (may affect up to 1 in 10 people):
- Allergic reaction (hypersensitivity)
- Being unable to sleep
- Feeling depressed, nervous or anxious
- Being aware of your heartbeat (palpitations)
- Varicose veins
- Flushing, skin reddening
- Breast pain
- Numb or tingling hands or feet
- Feeling sick (nausea)
- Stomach ache
- Pain including pain in the back or joints
- Painful periods
- Discharge from the vagina
- Irregular, heavy or prolonged bleeding from the vagina, including after sex
- Water retention or build-up of fluid under the skin (oedema)
- Feeling tired
- Weight gain
Uncommon (may affect up to 1 in 100 people):
- Vaginal infections such as thrush
- Less interest in sex than usual
- Itchy skin
- Swelling of the hands and feet (peripheral oedema)
- Muscle pain
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with Evorel Conti, please read the information provided with the medicine or consult your doctor or pharmacist.
Evorel conti should be used with caution if you have:
- fibroids inside your womb
- a growth of womb lining outside your womb (endometriosis) or a history of excessive growth of the womb lining (endometrial hyperplasia)
- increased risk of developing blood clots (thrombosis)
- increased risk of oestrogen-sensitive cancer (the risk is increased if your mother, grandmother or sister has, or has had, breast cancer)
- high blood pressure
- a liver disorder, such as a benign liver tumour
- migraine or severe headaches
- a disease of the immune system that affects many organs of the body (e.g.systemic lupus erythematosus, SLE)
- a disease affecting the eardrum and hearing (otosclerosis)
- a very high level of fat in your blood (triglycerides)
- fluid retention due to cardiac or kidney problems
Elleste Duet Conti should not be used if you:
- have or have ever had breast cancer, or if you are suspected of having it
- have cancer which is sensitive to oestrogens, such as cancer of the womb lining (endometrium), or if you are suspected of having it
- have any unexplained vaginal bleeding
- have excessive thickening of the womb lining (endometrial hyperplasia) and this is not being treated
- have or have ever had a blood clot in a vein (thrombosis), such as in the legs (deep venous thrombosis) or the lungs (pulmonary embolism)
- have a blood clotting disorder (such as protein C, protein S, or antithrombin deficiency)
- have or recently have had a disease caused by blood clots in the arteries, such as a heart attack, stroke or angina
- have or have ever had a liver disease and your liver function tests have not returned to normal
- have a rare blood problem called “porphyria” which is passed down in families (inherited)
Evorel Conti should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you think or feel that you have experienced an allergic reaction, inform your doctor or pharmacist immediately and immediately stop using this medicine.
The patient information leaflet (PIL) is a leaflet containing specific information about medical conditions, doses and side effects. You can download a copy of the PIL here:
Patient Info Leaflet